Discovery of <i>N</i>-(4-(3-isopropyl-2-methyl-2<i>H</i>-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies.

Huang, Jianhang; Wang, Xinren; Dong, Ruinan; Liu, Xiaoyue; Li, Hongmei; Zhang, Tianyi; Xu, Junyu; Liu, Chenhe; Zhang, Yanmin; Hou, Shaohua; Tang, Weifang; Lu, Tao; Chen, Yadong

Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies.

Huang, Jianhang; Wang, Xinren; Dong, Ruinan; Liu, Xiaoyue; Li, Hongmei; Zhang, Tianyi; Xu, Junyu; Liu, Chenhe; Zhang, Yanmin; Hou, Shaohua; Tang, Weifang; Lu, Tao; Chen, Yadong.

Afiliación

Huang J; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Wang X; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Dong R; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Liu X; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Li H; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Zhang T; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Xu J; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Liu C; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Zhang Y; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Hou S; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Tang W; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Lu T; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
Chen Y; School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.

J Med Chem ; 64(17): 12548-12571, 2021 09 09.

Article en En | MEDLINE | ID: mdl-34415148

Asunto(s)

Antineoplásicos/farmacología; Inhibidores de Proteínas Quinasas/química; Inhibidores de Proteínas Quinasas/farmacología; Administración Oral; Animales; Antineoplásicos/química; Área Bajo la Curva; Dominio Catalítico; Línea Celular Tumoral; Quinasa 9 Dependiente de la Ciclina/química; Quinasa 9 Dependiente de la Ciclina/metabolismo; Semivida; Humanos; Ratones; Estructura Molecular; Unión Proteica; Inhibidores de Proteínas Quinasas/farmacocinética; Relación Estructura-Actividad; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteínas Quinasas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article

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