A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines.
J Am Chem Soc
; 143(34): 13999-14008, 2021 09 01.
Article
en En
| MEDLINE
| ID: mdl-34424694
ABSTRACT
We introduce a new reagent class, 2-azatrienes, as a platform for catalytic enantioselective synthesis of allylic amines. Herein, we demonstrate their promise by a diastereodivergent synthesis of syn- and anti-1,2-diamines through their Cu-bis(phosphine)-catalyzed reductive couplings with imines. With Ph-BPE as the supporting ligand, anti-diamines are obtained (up to 91% yield, >201 dr, and >991 er), and with the rarely utilized t-Bu-BDPP, syn-diamines are generated (up to 76% yield, 1>20 dr, and 973 er).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Aza
/
Cobre
/
Diaminas
/
Compuestos Heterocíclicos
Idioma:
En
Revista:
J Am Chem Soc
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos