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Advances in the development of HIV integrase strand transfer inhibitors.
Wang, Yue; Gu, Shuang-Xi; He, Qiuqin; Fan, Renhua.
Afiliación
  • Wang Y; Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200438, China.
  • Gu SX; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China; Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic
  • He Q; Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200438, China. Electronic address: qqhe@fudan.edu.cn.
  • Fan R; Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200438, China.
Eur J Med Chem ; 225: 113787, 2021 Dec 05.
Article en En | MEDLINE | ID: mdl-34425310
ABSTRACT
HIV-1 integrase (IN) is a key enzyme in viral replication that catalyzes the covalent integration of viral cDNA into the host genome. Currently, five HIV-1 IN strand transfer inhibitors (INSTIs) are approved for clinical use. These drugs represent an important addition to the armamentarium for antiretroviral therapy. This review briefly illustrates the development history of INSTIs. The characteristics of the currently approved INSTIs, as well as their future perspectives, are critically discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: VIH-1 / Inhibidores de Integrasa VIH / Integrasa de VIH / Fármacos Anti-VIH / Desarrollo de Medicamentos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: VIH-1 / Inhibidores de Integrasa VIH / Integrasa de VIH / Fármacos Anti-VIH / Desarrollo de Medicamentos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China