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Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson-Gilford Progeria syndrome.
Cabral, Wayne A; Tavarez, Urraca L; Beeram, Indeevar; Yeritsyan, Diana; Boku, Yoseph D; Eckhaus, Michael A; Nazarian, Ara; Erdos, Michael R; Collins, Francis S.
Afiliación
  • Cabral WA; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Tavarez UL; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Beeram I; Translational Musculoskeletal Innovation Initiative, Carl J. Shapiro Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Yeritsyan D; Translational Musculoskeletal Innovation Initiative, Carl J. Shapiro Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Boku YD; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Eckhaus MA; Diagnostic and Research Services Branch, Division of Veterinary Resources, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
  • Nazarian A; Translational Musculoskeletal Innovation Initiative, Carl J. Shapiro Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Erdos MR; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Collins FS; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Aging Cell ; 20(9): e13457, 2021 09.
Article en En | MEDLINE | ID: mdl-34453483
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_endocrine_disorders Asunto principal: Progeria / Modelos Animales de Enfermedad / Serina-Treonina Quinasas TOR / Longevidad Límite: Animals / Humans Idioma: En Revista: Aging Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_endocrine_disorders Asunto principal: Progeria / Modelos Animales de Enfermedad / Serina-Treonina Quinasas TOR / Longevidad Límite: Animals / Humans Idioma: En Revista: Aging Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos