Broad-spectrum azoles and flucloxacillin: a dangerous match.
Eur J Clin Microbiol Infect Dis
; 41(1): 153-154, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34494173
ABSTRACT
Both invasive fungal infection with Aspergillus fumigatus and blood stream infection with methicillin-susceptible Staphylococcus aureus (MSSA) have a significant incidence in the critically ill. Voriconazole and, more recently, isavuconazole and high dose flucloxacillin are the standard first line treatments for these respective serious infections. However, an underestimated risk of a significant interaction needs to be taken into consideration, when both co-occur. We wish to highlight this important issue in the management of these patients through two case reports and to point to the inconsistency between different validated databases regarding this significant interaction as well the importance of a strict protocol for readily available therapeutic drug monitoring.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Aspergilosis
/
Infecciones Estafilocócicas
/
Triazoles
/
Interacciones Farmacológicas
/
Voriconazol
/
Floxacilina
/
Antibacterianos
/
Antifúngicos
/
Nitrilos
Tipo de estudio:
Guideline
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Microbiol Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Bélgica