Ocular disease-associated mutations diminish the mitotic chromosome retention ability of PAX6.

Lan, Hsin-Chi; Du, Ting-Huei; Yao, Ya-Li; Yang, Wen-Ming

Lan, Hsin-Chi; Du, Ting-Huei; Yao, Ya-Li; Yang, Wen-Ming.

Afiliación

Lan HC; Institute of Molecular Biology, National Chung Hsing University, Taichung 40227, Taiwan.
Du TH; Institute of Molecular Biology, National Chung Hsing University, Taichung 40227, Taiwan.
Yao YL; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan. Electronic address: yyao@asia.edu.tw.
Yang WM; Institute of Molecular Biology, National Chung Hsing University, Taichung 40227, Taiwan; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan. Electronic address: yangwm@nchu.edu.tw.

Biochim Biophys Acta Gene Regul Mech ; 1864(11-12): 194751, 2021.

Article en En | MEDLINE | ID: mdl-34500082

Asunto(s)

Cromosomas Humanos/metabolismo; Oftalmopatías/genética; Mitosis/genética; Factor de Transcripción PAX6/metabolismo; Células HEK293; Humanos; Microscopía Intravital; Mutación; Factor de Transcripción PAX6/genética

Palabras clave

DNA-binding; Intrinsically disordered regions (IDRs); Mitotic chromosome retention; Nuclear localization signals (NLS); Ocular disease; PAX6

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos / Oftalmopatías / Factor de Transcripción PAX6 / Mitosis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Biochim Biophys Acta Gene Regul Mech Año: 2021 Tipo del documento: Article País de afiliación: Taiwán

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