Copper-catalyzed enantioselective alkene carboetherification for the synthesis of saturated six-membered cyclic ethers.
Chem Commun (Camb)
; 57(78): 10099-10102, 2021 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-34518847
ABSTRACT
The enantioselective copper-catalyzed oxidative coupling of alkenols with styrenes for the construction of dihydropyrans, isochromans, pyrans and morpholines is reported. A concise formal synthesis of a σ1 receptor ligand using this alkene carboetherification methodology was demonstrated. Ligand, solvent and base all impact reaction efficiency. DFT transition state calculations are presented.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos