Copper-catalyzed enantioselective alkene carboetherification for the synthesis of saturated six-membered cyclic ethers.

Berhane, Ilyas A; Burde, Ameya S; Kennedy-Ellis, Jonathan J; Zurek, Eva; Chemler, Sherry R

Berhane, Ilyas A; Burde, Ameya S; Kennedy-Ellis, Jonathan J; Zurek, Eva; Chemler, Sherry R.

Afiliación

Berhane IA; Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York, 14260, USA. schemler@buffalo.edu.
Burde AS; Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York, 14260, USA. schemler@buffalo.edu.
Kennedy-Ellis JJ; Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York, 14260, USA. schemler@buffalo.edu.
Zurek E; Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York, 14260, USA. schemler@buffalo.edu.
Chemler SR; Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York, 14260, USA. schemler@buffalo.edu.

Chem Commun (Camb) ; 57(78): 10099-10102, 2021 Sep 30.

Article en En | MEDLINE | ID: mdl-34518847

ABSTRACT

ABSTRACT

The enantioselective copper-catalyzed oxidative coupling of alkenols with styrenes for the construction of dihydropyrans, isochromans, pyrans and morpholines is reported. A concise formal synthesis of a σ1 receptor ligand using this alkene carboetherification methodology was demonstrated. Ligand, solvent and base all impact reaction efficiency. DFT transition state calculations are presented.

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google