The Immune Response in Multiple Sclerosis.
Annu Rev Pathol
; 17: 121-139, 2022 01 24.
Article
en En
| MEDLINE
| ID: mdl-34606377
ABSTRACT
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells, triggering demyelination, axonal damage, and neurodegeneration. Although the exact causes of MS are not fully understood, genetic and environmental factors are thought to control MS onset and progression. In this article, we review the main immunological mechanisms involved in MS pathogenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Esclerosis Múltiple
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Pathol
Asunto de la revista:
PATOLOGIA
Año:
2022
Tipo del documento:
Article