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Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis.
Abo, Yara-Natalie; Curtis, Nigel; Osowicki, Joshua; Haeusler, Gabrielle; Purcell, Rachael; Kadambari, Seilesh; De Wachter, Matthias; Vanden Driessche, Koen; Dekeyzer, Sven; Coleman, Lee; Crawford, Nigel; Graham, Steve; Marais, Ben; Gwee, Amanda.
Afiliación
  • Abo YN; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Curtis N; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Osowicki J; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
  • Haeusler G; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Purcell R; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Kadambari S; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
  • De Wachter M; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Vanden Driessche K; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Dekeyzer S; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
  • Coleman L; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Crawford N; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Graham S; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Marais B; Division of Paediatric Neurology, Department of Paediatrics, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
  • Gwee A; Division of Paediatric Pulmonology, Department of Paediatrics, University Hospital Antwerp, Edegem, Belgium.
J Pediatric Infect Dis Soc ; 10(12): 1087-1091, 2021 Dec 31.
Article en En | MEDLINE | ID: mdl-34608937
Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_tuberculosis Asunto principal: Tuberculosis del Sistema Nervioso Central / Antituberculosos Tipo de estudio: Observational_studies Límite: Child / Humans Idioma: En Revista: J Pediatric Infect Dis Soc Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_tuberculosis Asunto principal: Tuberculosis del Sistema Nervioso Central / Antituberculosos Tipo de estudio: Observational_studies Límite: Child / Humans Idioma: En Revista: J Pediatric Infect Dis Soc Año: 2021 Tipo del documento: Article País de afiliación: Australia