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Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers.
Davenport, Adam J; Neagoe, Ioana; Bräuer, Nico; Koch, Markus; Rotgeri, Andrea; Nagel, Jens; Laux-Biehlmann, Alexis; Machet, Frederic; Coelho, Anne-Marie; Boyce, Susan; Carty, Nikisha; Gemkow, Mark J; Hess, Stephen D; Zollner, Thomas M; Fischer, Oliver M.
Afiliación
  • Davenport AJ; Discovery Chemistry, Dorothy Crowfoot Hodgkin Campus, Evotec UK, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK.
  • Neagoe I; In Vitro Pharmacology, Manfred Eigen Campus, Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Bräuer N; Research, In Vitro Biology, Galapagos, Generaal De Wittelaan L11 A3,, 2800, Mechlin, Belgium.
  • Koch M; Pharmaceuticals Division, Drug Discovery, Candidate Generation & Exploration, Medicinal Chemistry, Bayer AG, Müllerstr. 178, 13353, Berlin, Germany.
  • Rotgeri A; Life Sciences Chemistry, Nuvisan ICB GmbH, Müllerstr. 178, 13353, Berlin, Germany.
  • Nagel J; Pharmaceuticals Division, Research and Development, Preclinical Research, Therapeutic Area Endocrinology, Metabolism and Reproductive Health, Bayer AG, Müllerstr. 178, 13353, Berlin, Germany.
  • Laux-Biehlmann A; Pharmaceuticals Division, Drug Discovery, Early Development, Drug Metabolism and Pharmacokinetics, Bayer AG, Müllerstr. 178, 13353, Berlin, Germany.
  • Machet F; Preclinical Compound Profiling, Nuvisan ICB GmbH, Müllerstr. 178, 13353, Berlin, Germany.
  • Coelho AM; Pharmaceuticals Division, Research and Development, Preclinical Research, Therapeutic Area Endocrinology, Metabolism and Reproductive Health, Bayer AG, Müllerstr. 178, 13353, Berlin, Germany.
  • Boyce S; Research & Development, Pulmonary Drug Discovery Laboratory, Bayer US LLC, Boston, MA, USA.
  • Carty N; In Vivo Pharmacology, Campus Curie, Evotec SAS, 195 route d'Espagne, 31036, Toulouse, France.
  • Gemkow MJ; In Vivo Pharmacology, Manfred Eigen Campus, Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Hess SD; In Vivo Pharmacology, Manfred Eigen Campus, Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Zollner TM; In Vitro Pharmacology, Manfred Eigen Campus, Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
  • Fischer OM; Neurosciences, Manfred Eigen Campus, Evotec SE, Essener Bogen 7, 22419, Hamburg, Germany.
Sci Rep ; 11(1): 19877, 2021 10 06.
Article en En | MEDLINE | ID: mdl-34615939
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Somatosensoriales / Receptores Purinérgicos P2X3 / Antagonistas del Receptor Purinérgico P2X / Fibras Nerviosas Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Somatosensoriales / Receptores Purinérgicos P2X3 / Antagonistas del Receptor Purinérgico P2X / Fibras Nerviosas Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido