Sleep duration and risk of hyperlipidemia: a systematic review and meta-analysis of prospective studies.

ABSTRACT

PURPOSE: Current studies indicate that the association between sleep duration and risk of hyperlipidemia is uncertain. This systematic review aimed to evaluate relevant prospective studies and make a definite conclusion. METHODS: Three databases were searched for prospective studies on the relationship between sleep duration and hyperlipidemia risk from their inception to October 2020. RESULTS: We identified twelve studies involving 114,439 participants. Follow-up for incident hyperlipidemia ranged from 200 days to 10 years. Neither long (RR1.00, 95%CI0.90-1.11, P > 0.05) nor short (RR0.99, 95%CI0.94-1.05, P > 0.05) sleep duration had a significant association with increased hyperlipidemia risk in adults. However, long sleep duration was decidedly associated with low HDL-C (RR0.19, 95%CI - 0.03-0.40, P < 0.05) and high triglycerides (RR - 0.20, 95%CI - 0.43-0.03, P < 0.05) in children and adolescents. CONCLUSION: Long sleep duration has strong associations with risks of low HDL-C and high triglycerides in children and adolescents. The mechanisms underlying this association deserves to be explored in future studies.