Your browser doesn't support javascript.
loading
Concordance of immunological events between intrarectal and intravenous SHIVAD8-EO infection when assessed by Fiebig-equivalent staging.
Dias, Joana; Fabozzi, Giulia; March, Kylie; Asokan, Mangaiarkarasi; Almasri, Cassandra G; Fintzi, Jonathan; Promsote, Wanwisa; Nishimura, Yoshiaki; Todd, John-Paul; Lifson, Jeffrey D; Martin, Malcolm A; Gama, Lucio; Petrovas, Constantinos; Pegu, Amarendra; Mascola, John R; Koup, Richard A.
Afiliación
  • Dias J; Immunology Laboratory, Vaccine Research Center.
  • Fabozzi G; Tissue Analysis Core, Vaccine Research Center.
  • March K; Tissue Analysis Core, Vaccine Research Center.
  • Asokan M; Virology Laboratory, Vaccine Research Center.
  • Almasri CG; Virology Laboratory, Vaccine Research Center.
  • Fintzi J; Biostatistics Research Branch.
  • Promsote W; Immunology Laboratory, Vaccine Research Center.
  • Nishimura Y; Laboratory of Molecular Biology, and.
  • Todd JP; Translational Research Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Lifson JD; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Martin MA; Laboratory of Molecular Biology, and.
  • Gama L; Immunology Laboratory, Vaccine Research Center.
  • Petrovas C; Tissue Analysis Core, Vaccine Research Center.
  • Pegu A; Virology Laboratory, Vaccine Research Center.
  • Mascola JR; Virology Laboratory, Vaccine Research Center.
  • Koup RA; Immunology Laboratory, Vaccine Research Center.
J Clin Invest ; 131(17)2021 09 01.
Article en En | MEDLINE | ID: mdl-34623326
ABSTRACT
Primary HIV-1 infection can be classified into six Fiebig stages based on virological and serological laboratory testing, whereas simian-HIV (SHIV) infection in nonhuman primates (NHPs) is defined in time post-infection, making it difficult to extrapolate NHP experiments to the clinics. We identified and extensively characterized the Fiebig-equivalent stages in NHPs challenged intrarectally or intravenously with SHIVAD8-EO. During the first month post-challenge, intrarectally challenged monkeys were up to 1 week delayed in progression through stages. However, regardless of the challenge route, stages I-II predominated before, and stages V-VI predominated after, peak viremia. Decrease in lymph node (LN) CD4+ T cell frequency and rise in CD8+ T cells occurred at stage V. LN virus-specific CD8+ T cell responses, dominated by degranulation and TNF, were first detected at stage V and increased at stage VI. A similar late elevation in follicular CXCR5+ CD8+ T cells occurred, consistent with higher plasma CXCL13 levels at these stages. LN SHIVAD8-EO RNA+ cells were present at stage II, but appeared to decline at stage VI when virions accumulated in follicles. Fiebig-equivalent staging of SHIVAD8-EO infection revealed concordance of immunological events between intrarectal and intravenous infection despite different infection progressions, and can inform comparisons of NHP studies with clinical data.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 Problema de salud: 1_geracao_evidencia_conhecimento / 2_enfermedades_transmissibles Asunto principal: Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Clin Invest Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 Problema de salud: 1_geracao_evidencia_conhecimento / 2_enfermedades_transmissibles Asunto principal: Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Clin Invest Año: 2021 Tipo del documento: Article
...