The Role of Non-essential Amino Acids in T Cell Function and Anti-tumour Immunity.
Arch Immunol Ther Exp (Warsz)
; 69(1): 29, 2021 Oct 12.
Article
en En
| MEDLINE
| ID: mdl-34637000
ABSTRACT
T cell activation, differentiation and proliferation is dependent upon and intrinsically linked to a capacity to modulate and adapt cellular metabolism. Antigen-induced activation stimulates a transcriptional programme that results in metabolic reprogramming, enabling T cells to fuel anabolic metabolic pathways and provide the nutrients to sustain proliferation and effector responses. Amino acids are key nutrients for T cells and have essential roles as building blocks for protein synthesis as well as in numerous metabolic pathways. In this review, we discuss the roles for uptake and biosynthesis of non-essential amino acids in T cell metabolism, activation and effector function. Furthermore, we highlight the effects of amino acid metabolism and depletion by cancer cells on T cell anti-tumour function and discuss approaches to modulate and improve T cell metabolism for improved anti-tumour function in these nutrient-depleted microenvironments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Arch Immunol Ther Exp (Warsz)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suiza