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Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet, Antoine; Bohsali, Anastasia; Krishnamurthy, Lisa C; Shahid, Salman; Lin, Qixiang; Zhao, Liping; Loring, David; Goldstein, Felicia; John, Samantha E; Fleischer, Candace C; Levey, Allan; Lah, James; Qiu, Deqiang; Crosson, Bruce.
Afiliación
  • Hone-Blanchet A; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia. Electronic address: antoine.hone-blanchet@emory.edu.
  • Bohsali A; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
  • Krishnamurthy LC; Department of Physics & Astronomy, Georgia State University, Atlanta, Georgia; Center for Visual and Neurocognitive Rehabilitation, VA Medical Center, Decatur, Georgia.
  • Shahid S; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indianapolis.
  • Lin Q; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
  • Zhao L; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Loring D; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
  • Goldstein F; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
  • John SE; Department of Brain Health, Population Health & Health Equity Initiative, University of Nevada, Las Vegas, Nevada.
  • Fleischer CC; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia; Department of Joint Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.
  • Levey A; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
  • Lah J; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia.
  • Qiu D; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia; Department of Joint Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.
  • Crosson B; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia; Center for Visual and Neurocognitive Rehabilitation, VA Medical Center, Decatur, Georgia; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia.
Neurobiol Aging ; 109: 22-30, 2022 01.
Article en En | MEDLINE | ID: mdl-34638000
Elevated expression of ß-amyloid (Aß1-42) and tau are considered risk-factors for Alzheimer's disease in healthy older adults. We investigated the effect of aging and cerebrospinal fluid levels of Aß1-42 and tau on 1) frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and 2) cognition in cognitively normal older adults (n = 144; age range 50-85). Levels of frontal gamma aminobutyric acid (GABA+) and myo-inositol relative to creatine (mI/tCr) were predicted by age. Levels of GABA+ predicted cognitive performance better than mI/tCr. Additionally, we found that frontal levels of n-acetylaspartate relative to creatine (tNAA/tCr) were predicted by levels of t-tau. In cognitively normal older adults, levels of frontal GABA+ and mI/tCr are predicted by aging, with levels of GABA+ decreasing with age and the opposite for mI/tCr. These results suggest that age- and biomarker-related changes in brain metabolites are not only located in the posterior cortex as suggested by previous studies and further demonstrate that MRS is a viable tool in the study of aging and biomarkers associated with pathological aging and Alzheimer's disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Envejecimiento / Péptidos beta-Amiloides / Proteínas tau / Cognición / Enfermedad de Alzheimer / Lóbulo Frontal Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Neurobiol Aging Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Envejecimiento / Péptidos beta-Amiloides / Proteínas tau / Cognición / Enfermedad de Alzheimer / Lóbulo Frontal Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Neurobiol Aging Año: 2022 Tipo del documento: Article