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Longitudinal Changes in Scotopic and Mesopic Macular Function as Assessed with Microperimetry in Patients With Stargardt Disease: SMART Study Report No. 2.
Kong, Xiangrong; Ibrahim-Ahmed, Mohamed; Bittencourt, Millena G; Strauss, Rupert W; Birch, David G; Cideciyan, Artur V; Ervin, Ann-Margaret; Ho, Alexander; Sunness, Janet S; Audo, Isabelle S; Michaelides, Michel; Zrenner, Eberhart; Sadda, SriniVas; Ip, Michael S; West, Sheila; Scholl, Hendrik P N.
Afiliación
  • Kong X; Wilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA; Department of Biostatistics (X.K.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA; Department of Epidemiology (X.K., A.-M.E.), Bloomberg Sch
  • Ibrahim-Ahmed M; Ocular Imaging Research and Reading Center (M.I.-A.), Sunnyvale, California, USA.
  • Bittencourt MG; Wilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA.
  • Strauss RW; Moorfields Eye Hospital and UCL Institute of Ophthalmology (R.W.S., M.M.), London, UK; Department of Ophthalmology (R.W.S.), Kepler University Clinic, Linz, Linz, Austria; Department of Ophthalmology (R.W.S.), Medical University of Graz, Graz, Austria.
  • Birch DG; Retina Foundation of the Southwest (D.G.B.), Dallas, Texas, USA.
  • Cideciyan AV; Scheie Eye Institute (A.V.C.), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Ervin AM; Wilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA; Department of Epidemiology (X.K., A.-M.E.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
  • Ho A; Doheny Image Reading Center (A.H., S.V.S., M.S.I.), Los Angeles, California, USA.
  • Sunness JS; Greater Baltimore Medical Center (J.S.S.), Baltimore, Maryland, USA.
  • Audo IS; CHNO des Quinze-Vingts (I.S.A.), DHU Sight Restore, INSERM-DHOS CIC 1423, Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, Paris, France.
  • Michaelides M; Moorfields Eye Hospital and UCL Institute of Ophthalmology (R.W.S., M.M.), London, UK.
  • Zrenner E; Universitäts-Augenklinik (E.Z.), University of Tübingen, Tübingen, Germany.
  • Sadda S; Doheny Image Reading Center (A.H., S.V.S., M.S.I.), Los Angeles, California, USA.
  • Ip MS; Doheny Image Reading Center (A.H., S.V.S., M.S.I.), Los Angeles, California, USA.
  • West S; Wilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA.
  • Scholl HPN; Wilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA; Institute of Molecular and Clinical Ophthalmology Basel (IOB) (H.P.N.S.), Basel, Switzerland; Department of Ophthalmology (H.P.N.S.), University of Basel, Basel, Switzerland.
Am J Ophthalmol ; 236: 32-44, 2022 04.
Article en En | MEDLINE | ID: mdl-34695402
ABSTRACT

PURPOSE:

To estimate and compare cross-sectional scotopic versus mesopic macular sensitivity losses measured by microperimetry, and to report and compare the longitudinal rates of scotopic and mesopic macular sensitivity losses in ABCA4 gene-associated Stargardt disease (STGD1).

DESIGN:

This was a multicenter prospective cohort study.

METHODS:

Participants comprised 127 molecularly confirmed STGD1 patients enrolled from 6 centers in the United States and Europe and followed up every 6 months for up to 2 years. The Nidek MP-1S device was used to measure macular sensitivities of the central 20° under mesopic and scotopic conditions. The mean deviations (MD) from normal for mesopic macular sensitivity for the fovea (within 2° eccentricity) and extrafovea (4°-10° eccentricity), and the MD for scotopic sensitivity for the extrafovea, were calculated. Linear mixed effects models were used to estimate mesopic and scotopic changes. Main outcome measures were baseline mesopic mean deviation (mMD) and scotopic MD (sMD) and rates of longitudinal changes in the mMDs and sMD.

RESULTS:

At baseline, all eyes had larger sMD, and the difference between extrafoveal sMD and mMD was 10.7 dB (P < .001). Longitudinally, all eyes showed a statistically significant worsening trend the rates of foveal mMD and extrafoveal mMD and sMD changes were 0.72 (95% CI = 0.37-1.07), 0.86 (95% CI = 0.58-1.14), and 1.12 (95% CI = 0.66-1.57) dB per year, respectively.

CONCLUSIONS:

In STGD1, in extrafovea, loss of scotopic macular function preceded and was faster than the loss of mesopic macular function. Scotopic and mesopic macular sensitivities using microperimetry provide alternative visual function outcomes for STGD1 treatment trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas del Campo Visual / Degeneración Macular Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Am J Ophthalmol Año: 2022 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas del Campo Visual / Degeneración Macular Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Am J Ophthalmol Año: 2022 Tipo del documento: Article