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DNA damage and aging on hematopoietic stem cells: Impact of oxidative stress in ApoE-/- mice.
Aires, R; Porto, M L; de Assis, L M; Pereira, P A N; Carvalho, G R; Côco, L Z; Vasquez, E C; Pereira, T M C; Campagnaro, B P; Meyrelles, S S.
Afiliación
  • Aires R; Laboratory of Translational Physiology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, Brazil. Electronic address: silvana.meyrelles@ufes.br.
  • Porto ML; Federal Institute of Education, Science and Technology (IFES), Vila Velha, ES, Brazil.
  • de Assis LM; Federal Institute of Education, Science and Technology (IFES), Vila Velha, ES, Brazil.
  • Pereira PAN; Federal Institute of Education, Science and Technology (IFES), Vila Velha, ES, Brazil.
  • Carvalho GR; Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
  • Côco LZ; Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
  • Vasquez EC; Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
  • Pereira TMC; Federal Institute of Education, Science and Technology (IFES), Vila Velha, ES, Brazil; Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
  • Campagnaro BP; Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
  • Meyrelles SS; Laboratory of Translational Physiology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, Brazil.
Exp Gerontol ; 156: 111607, 2021 12.
Article en En | MEDLINE | ID: mdl-34715304
ABSTRACT
The effects of aging on ROS production and DNA damage were assessed in hematopoietic stem cells (HSCs) from apolipoprotein E-deficient (ApoE-/-) mice (2-, 12- and 24-month-old), a traditional experimental model of atherogenic dyslipidemia. HSCs from aged ApoE-/- mice were associated with increased ROS levels, leading to loss quiescence, DNA damage, apoptosis and telomere shortening. The concurrence of lack of ApoE and aging result in exhaustion and senescence of HSCs accompanied by increased oxidative stress and inflammation. Therefore, our data open avenues to a better understanding of age-related changes and genetic factors, which may synergistically compromise the efficacy of aged HSC recovery and/or transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Estrés Oxidativo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Gerontol Año: 2021 Tipo del documento: Article
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Estrés Oxidativo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Gerontol Año: 2021 Tipo del documento: Article