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Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity.
Bido, Simone; Muggeo, Sharon; Massimino, Luca; Marzi, Matteo Jacopo; Giannelli, Serena Gea; Melacini, Elena; Nannoni, Melania; Gambarè, Diana; Bellini, Edoardo; Ordazzo, Gabriele; Rossi, Greta; Maffezzini, Camilla; Iannelli, Angelo; Luoni, Mirko; Bacigaluppi, Marco; Gregori, Silvia; Nicassio, Francesco; Broccoli, Vania.
Afiliación
  • Bido S; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Muggeo S; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Massimino L; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Marzi MJ; Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), 20139, Milan, Italy.
  • Giannelli SG; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Melacini E; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Nannoni M; National Research Council (CNR), Institute of Neuroscience, 20129, Milan, Italy.
  • Gambarè D; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Bellini E; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Ordazzo G; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Rossi G; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Maffezzini C; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Iannelli A; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Luoni M; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Bacigaluppi M; National Research Council (CNR), Institute of Neuroscience, 20129, Milan, Italy.
  • Gregori S; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
  • Nicassio F; Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Broccoli V; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Nat Commun ; 12(1): 6237, 2021 10 29.
Article en En | MEDLINE | ID: mdl-34716339
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Microglía / Alfa-Sinucleína / Neuronas Dopaminérgicas / Degeneración Nerviosa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Italia
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Microglía / Alfa-Sinucleína / Neuronas Dopaminérgicas / Degeneración Nerviosa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Italia