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Fatty acids may influence insulin dynamics through modulation of albumin-Zn2+ interactions.
Arya, Swati; Gourley, Adam J; Penedo, J Carlos; Blindauer, Claudia A; Stewart, Alan J.
Afiliación
  • Arya S; School of Medicine, University of St. Andrews, St. Andrews, Fife, UK.
  • Gourley AJ; School of Medicine, University of St. Andrews, St. Andrews, Fife, UK.
  • Penedo JC; Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife, UK.
  • Blindauer CA; Department of Chemistry, University of Warwick, Coventry, UK.
  • Stewart AJ; School of Medicine, University of St. Andrews, St. Andrews, Fife, UK.
Bioessays ; 43(12): e2100172, 2021 12.
Article en En | MEDLINE | ID: mdl-34725844
ABSTRACT
Insulin is stored within the pancreas in an inactive Zn2+ -bound hexameric form prior to release. Similarly, clinical insulins contain Zn2+ and form multimeric complexes. Upon release from the pancreas or upon injection, insulin only becomes active once Zn2+ disengages from the complex. In plasma and other extracellular fluids, the majority of Zn2+ is bound to human serum albumin (HSA), which plays a vital role in controlling insulin pharmacodynamics by enabling removal of Zn2+ . The Zn2+ -binding properties of HSA are attenuated by non-esterified fatty acids (NEFAs) also transported by HSA. Elevated NEFA concentrations are associated with obesity and type 2 diabetes. Here we present the hypothesis that higher NEFA levels in obese and/or diabetic individuals may contribute to insulin resistance and affect therapeutic insulin dose-response profiles, through modulation of HSA/Zn2+ dynamics. We envisage this novel concept to have important implications for personalized treatments and management of diabetes-related conditions in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Ácidos Grasos Límite: Humans Idioma: En Revista: Bioessays Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Ácidos Grasos Límite: Humans Idioma: En Revista: Bioessays Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
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