Sitagliptin's renoprotective effect in a diabetic nephropathy model in rats: The potential role of PI3K/AKT pathway.

Mohamed, Reham Hussein; Sedky, Amina Ahmed; Hamam, Ghada Galal; Elkhateb, Lobna; Kamar, Sherif A; Adel, Seham; Tawfik, Sherin Shafik

Mohamed, Reham Hussein; Sedky, Amina Ahmed; Hamam, Ghada Galal; Elkhateb, Lobna; Kamar, Sherif A; Adel, Seham; Tawfik, Sherin Shafik.

Afiliación

Mohamed RH; Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Sedky AA; Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hamam GG; Department of Histology and cell biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Elkhateb L; Department of Histology and cell biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Kamar SA; Department of Anatomy, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Adel S; Department of Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Tawfik SS; Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Fundam Clin Pharmacol ; 36(2): 324-337, 2022 Apr.

Article en En | MEDLINE | ID: mdl-34735026

Asunto(s)

Diabetes Mellitus Experimental; Nefropatías Diabéticas; Animales; Diabetes Mellitus Experimental/complicaciones; Diabetes Mellitus Experimental/tratamiento farmacológico; Diabetes Mellitus Experimental/metabolismo; Nefropatías Diabéticas/tratamiento farmacológico; Nefropatías Diabéticas/prevención & control; Riñón; Masculino; Fosfatidilinositol 3-Quinasa/metabolismo; Fosfatidilinositol 3-Quinasa/farmacología; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas; Ratas Wistar; Fosfato de Sitagliptina/metabolismo; Fosfato de Sitagliptina/farmacología

Palabras clave

diabetic nephropathy; phosphatidylinositol 3-kinase; protein kinase B; sitagliptin; α-SMA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Diabetes Mellitus Experimental / Nefropatías Diabéticas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Egipto

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