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Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants.
Li, Haoting; Mattingly, Anne E; Jania, Leigh A; Smith, Richard; Melander, Roberta J; Ernst, Robert K; Koller, Beverley H; Melander, Christian.
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  • Li H; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
  • Mattingly AE; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
  • Jania LA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • Smith R; Department of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland 21201, United States.
  • Melander RJ; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
  • Ernst RK; Department of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland 21201, United States.
  • Koller BH; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • Melander C; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
ACS Infect Dis ; 7(12): 3303-3313, 2021 12 10.
Article en En | MEDLINE | ID: mdl-34752055
Multidrug-resistant bacterial infections have become a global threat. We recently disclosed that the known IKK-ß inhibitor IMD-0354 and subsequent analogues abrogate colistin resistance in several Gram-negative strains. Herein, we report the activity of a second-generation library of IMD-0354 analogues incorporating a benzimidazole moiety as an amide isostere. We identified several analogues that show increased colistin potentiation activity against Gram-negative bacteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salicilanilidas / Colistina Idioma: En Revista: ACS Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salicilanilidas / Colistina Idioma: En Revista: ACS Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos