Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.
Biophys Rev
; 13(5): 769-786, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34777617
ABSTRACT
The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biological processes underlying the dysfunction of this multifaceted system. In this review, we discuss the unique ability of microfluidic systems to recapitulate the biophysical, biochemical, and functional properties of the human circulatory system. We also describe the remarkable capacity of microfluidic technologies for exploring the complex mechanobiology of the cardiovascular system, mechanistic studying of cardiovascular diseases, and screening cardiovascular drugs with the additional benefit of reducing the need for animal models. We also discuss opportunities for further advancement in this exciting field.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Biophys Rev
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia