DPYD polymorphisms c.496A>G, c.2194G>A and c.85T>C and risk of severe adverse drug reactions in patients treated with fluoropyrimidine-based protocols.

Bozina, Nada; Bilic, Ivan; Ganoci, Lana; Simicevic, Livija; Plestina, Stjepko; Lesnjakovic, Lucija; Trkulja, Vladimir

Bozina, Nada; Bilic, Ivan; Ganoci, Lana; Simicevic, Livija; Plestina, Stjepko; Lesnjakovic, Lucija; Trkulja, Vladimir.

Afiliación

Bozina N; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.
Bilic I; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Ganoci L; Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia.
Simicevic L; School of Medicine, University of Zagreb, Croatia.
Plestina S; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Lesnjakovic L; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Trkulja V; Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia.

Br J Clin Pharmacol ; 88(5): 2190-2202, 2022 05.

Article en En | MEDLINE | ID: mdl-34780066

Asunto(s)

Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos; Neoplasias; Adulto; Antimetabolitos; Teorema de Bayes; Dihidrouracilo Deshidrogenasa (NADP)/genética; Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/genética; Fluorouracilo/efectos adversos; Genotipo; Humanos; Irinotecán/efectos adversos; Neoplasias/inducido químicamente; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Polimorfismo de Nucleótido Simple

Palabras clave

DPYD; adverse drug reactions; dihydropyrimidine dehydrogenase; fluoropyrimidines; pharmacogenetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_diarrhea Asunto principal: Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Neoplasias Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Br J Clin Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Croacia

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