Macrophages in Microbial Pathogenesis: Commonalities of Defense Evasion Mechanisms.
Infect Immun
; 90(5): e0029121, 2022 05 19.
Article
en En
| MEDLINE
| ID: mdl-34780281
ABSTRACT
Macrophages are key arsenals of the immune system against invaders. After compartmental isolation of a pathogen in phagosomes, the host immune response attempts to neutralize the pathogen. However, pathogens possess the ability to subvert these assaults and can also convert macrophages into their replicative niche. The multiple host defense evasion mechanisms employed by these pathogens include phagosome maturation arrest, molecular mimicry through secretory antigens, interference with host signaling, active radical neutralization, inhibition of phagosome acidification, alteration of programmed cell death, and other mechanisms. Macrophage biology as a part of the host-pathogen interaction has expanded rapidly in the past decade. The present review aims to shed some light upon the macrophage defense evasion strategies employed by pathogens. We have also incorporated recent knowledge in the field of macrophage dynamics during infection and evolutionary perspectives of macrophage dynamics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fagosomas
/
Evasión Inmune
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Infect Immun
Año:
2022
Tipo del documento:
Article
País de afiliación:
India