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Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
Cable, Jennifer; Leonard, Joshua N; Lu, Timothy K; Xie, Zhen; Chang, Matthew Wook; Fernández, Luis Ángel; Lora, José M; Kaufman, Howard L; Quintana, Francisco J; Geiger, Roger; F Lesser, Cammie; Lynch, Jason P; Hava, David L; Cornish, Virginia W; Lee, Gary K; DiAndreth, Breanna; Fero, Michael; Srivastava, Rajkamal; De Coster, Tim; Roybal, Kole T; Rackham, Owen J L; Kiani, Samira; Zhu, Iowis; Hernandez-Lopez, Rogelio A; Guo, Tingxi; Chen, William C W.
Afiliación
  • Cable J; PhD Science Writer, New York, New York.
  • Leonard JN; Department of Chemical and Biological Engineering, Center for Synthetic Biology, Interdisciplinary Biological Sciences Program, Chemistry of Life Processes Institute; and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois.
  • Lu TK; Research Lab of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Xie Z; Senti Biosciences, South San Francisco, California.
  • Chang MW; MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
  • Fernández LÁ; Synthetic Biology Translational Research Program and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore.
  • Lora JM; Department of Microbial Biotechnology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain.
  • Kaufman HL; Intergalactic Therapeutics, Cambridge, Massachusetts.
  • Quintana FJ; Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts.
  • Geiger R; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston and The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
  • F Lesser C; Institute for Research in Biomedicine, and Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.
  • Lynch JP; Department of Microbiology, Blavatnik Institute, Harvard Medical School and Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
  • Hava DL; Department of Microbiology, Blavatnik Institute, Harvard Medical School and Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
  • Cornish VW; Research Lab of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Lee GK; Department of Chemistry, Columbia University, New York, New York.
  • DiAndreth B; Senti Biosciences, South San Francisco, California.
  • Fero M; A2 Biotherapeutics, Agoura Hills, California.
  • Srivastava R; TeselaGen Biotechnology, San Francisco, California.
  • De Coster T; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Homi Bhabha National Institute (HBNI), Kolkata, India.
  • Roybal KT; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Rackham OJL; Department of Microbiology and Immunology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
  • Kiani S; Chan Zuckerberg Biohub; Parker Institute for Cancer Immunotherapy, Gladstone-UCSF Institute for Genomic Immunology; and UCSF Cell Design Institute, San Francisco, California.
  • Zhu I; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore.
  • Hernandez-Lopez RA; Division of Experimental Pathology, Department of Pathology, School of Medicine; and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Guo T; University of California, San Francisco, San Francisco, California.
  • Chen WCW; Cell Design Institute, Department of Cellular and Molecular Pharmacology; and Center for Cellular Construction, University of California San Francisco, San Francisco, California.
Ann N Y Acad Sci ; 1506(1): 98-117, 2021 12.
Article en En | MEDLINE | ID: mdl-34786712
ABSTRACT
Synthetic biology has the potential to transform cell- and gene-based therapies for a variety of diseases. Sophisticated tools are now available for both eukaryotic and prokaryotic cells to engineer cells to selectively achieve therapeutic effects in response to one or more disease-related signals, thus sparing healthy tissue from potentially cytotoxic effects. This report summarizes the Keystone eSymposium "Synthetic Biology At the Crossroads of Genetic Engineering and Human Therapeutics," which took place on May 3 and 4, 2021. Given that several therapies engineered using synthetic biology have entered clinical trials, there was a clear need for a synthetic biology symposium that emphasizes the therapeutic applications of synthetic biology as opposed to the technical aspects. Presenters discussed the use of synthetic biology to improve T cell, gene, and viral therapies, to engineer probiotics, and to expand upon existing modalities and functions of cell-based therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Ingeniería Genética / Congresos como Asunto / Biología Sintética / Informe de Investigación Límite: Animals / Humans Idioma: En Revista: Ann N Y Acad Sci Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Ingeniería Genética / Congresos como Asunto / Biología Sintética / Informe de Investigación Límite: Animals / Humans Idioma: En Revista: Ann N Y Acad Sci Año: 2021 Tipo del documento: Article