Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.
Sci Immunol
; 7(67): eabk3070, 2022 01 21.
Article
en En
| MEDLINE
| ID: mdl-34793243
ABSTRACT
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multiomic technology to generate a unified ex vivo characterization of the CD8+ T cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across four major HLA class I alleles. We found that HLA genotype conditions key features of epitope specificity, TCRα/ß sequence diversity, and the utilization of pre-existing SARS-CoV-2-reactive memory T cell pools. Single-cell transcriptomics revealed functionally diverse T cell phenotypes of SARS-CoV-2-reactive T cells, associated with both disease stage and epitope specificity. Our results show that HLA variations notably influence the CD8+ T cell repertoire shape and utilization of immune recall upon SARS-CoV-2 infection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
4_TD
Problema de salud:
4_pneumonia
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Receptores de Antígenos de Linfocitos T alfa-beta
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Linfocitos T CD8-positivos
/
Alelos
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SARS-CoV-2
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COVID-19
/
Células T de Memoria
Límite:
Humans
Idioma:
En
Revista:
Sci Immunol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos