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Detecting Mycobacterium Tuberculosis using a nitrofuranyl calanolide-trehalose probe based on nitroreductase Rv2466c.
Li, Xueyuan; Geng, Pengfei; Hong, Xiaoqiao; Sun, Zhaogang; Liu, Gang.
Afiliación
  • Li X; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China. gangliu27@tsinghua.edu.cn.
  • Geng P; Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China.
  • Hong X; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China. gangliu27@tsinghua.edu.cn.
  • Sun Z; School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China. gangliu27@tsinghua.edu.cn.
  • Liu G; Translational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. sunzg75@163.com.
Chem Commun (Camb) ; 57(97): 13174-13177, 2021 Dec 07.
Article en En | MEDLINE | ID: mdl-34812827
A new Mtb fluorescent probe, NFC-Tre-5, was reported that could label single cells of Mtb under various stress conditions via a unique fluorescence off-on feature by a Rv2466c-mediated reductive mechanism. This probe effectively facilitates the rapid and specific detection of Mtb in the host cell during infection and the detection of Mtb in sputum samples from patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND / 4_TD Problema de salud: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_tuberculosis / 4_tuberculosis Asunto principal: Trehalosa / Nitrorreductasas / Piranocumarinas / Colorantes Fluorescentes / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND / 4_TD Problema de salud: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_tuberculosis / 4_tuberculosis Asunto principal: Trehalosa / Nitrorreductasas / Piranocumarinas / Colorantes Fluorescentes / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article