Jiaotaiwan increased GABA level in brain and serum, improved sleep via increasing NREM sleep and REM sleep, and its component identification.
J Ethnopharmacol
; 285: 114866, 2022 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-34822960
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Jiaotaiwan (JTW) is good at communicating the heart and kidney. That meets the main mechanism of insomnia in traditional Chinese medicine. But the mechanism of JTW in promoting sleep is not clear. AIM OF THE STUDY To investigate the mechanism of JTW in promoting sleep and identify the main components. MATERIALS AND METHODS:
In this study, we detected the levels of GABA in serum and brain via LC-MS/MS analysis and investigated the hypnotic effect of JTW and its role in promoting sleep via Sleep monitoring and vigilance state analysis. Further, the identification of the main components was carried out by using LC-MS/MS analysis.RESULTS:
JTW could increase the GABA levels in serum, FC and BS of SDM rats. JTW reduced the amount of wakefulness, increased the time of NREM sleep and REM sleep. A total of 25 compounds were identified.CONCLUSIONS:
The current work provides valuable information on the hypnotic effects of JTW and its regulatory mechanisms in promoting sleep.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sueño
/
Sueño REM
/
Encéfalo
/
Medicamentos Herbarios Chinos
/
Ácido gamma-Aminobutírico
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Año:
2022
Tipo del documento:
Article
País de afiliación:
China