Discovery of novel phenaleno isoquinolinium-based fluorescence imaging agents for sentinel lymph node mapping.
J Mater Chem B
; 9(48): 9946-9950, 2021 12 15.
Article
en En
| MEDLINE
| ID: mdl-34852032
ABSTRACT
Fluorescence imaging agents have recently received huge attention due to their important role in disease diagnostics. However, the intrinsic problems of these probes, such as complex synthetic routes and high molecular weight, remain challenging. Here, we developed novel phenaleno isoquinolinium-based fluorescent agents, Medical Fluorophores 37-41 (MF37-41), applicable to the quantitative and sensitive detection of sentinel lymph nodes (SLNs). These imaging agents showed no adverse effects on the proliferation of immune and normal cells and did not induce in vivo toxicity. In vivo fluorescence lifetime imaging demonstrated the accumulation of phenaleno isoquinolinium salts in the SLNs of nude mice within 15 min postinjection, consistent with our biodistribution findings. These results suggest that phenaleno isoquinolinium salts are feasible fluorescence imaging agents that can be used as potential lymphatic tracers.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Fenalenos
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Descubrimiento de Drogas
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Imagen Óptica
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Colorantes Fluorescentes
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Ganglio Linfático Centinela
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Isoquinolinas
Límite:
Animals
Idioma:
En
Revista:
J Mater Chem B
Año:
2021
Tipo del documento:
Article
País de afiliación:
Corea del Sur