Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis.
Expert Rev Mol Diagn
; 22(2): 201-211, 2022 Feb.
Article
en En
| MEDLINE
| ID: mdl-34906021
ABSTRACT
PURPOSE:
Brain tumors (BT) are among the most prevalent cancers in recent years. Various studies have examined the diagnostic role of microRNAs in different diseases; however, their diagnostic role in BT has not been comprehensively investigated. This meta-analysis was performed to assess microRNAs in the blood of patients with BTs accurately.METHODS:
Twenty-six eligible studies were included for analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under curve (AUC), Q*index, summary receiver-operating characteristic (SROC) were assessed using the Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.3.3 software.RESULTS:
The diagnostic accuracy of microRNA was high in identifying BT based on the pooled sensitivity 0.82 (95%CI 0.816-0.84), specificity 0.82 (95%CI 0.817-0.84), PLR 5.101 (95%CI 3.99-6.51), NLR 0.187 (95%CI 0.149-0.236), DOR 34.07 (95%CI 22.56-51.43) as well as AUC (0.92), and Q*-index (0.86). Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR.CONCLUSION:
This meta-analysis suggested that circulating microRNAs might be potential markers for noninvasive early detection of BT.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
MicroARNs
/
MicroARN Circulante
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Expert Rev Mol Diagn
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2022
Tipo del documento:
Article
País de afiliación:
Irán