Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.
JID Innov
; 1(1): 100001, 2021 Mar.
Article
en En
| MEDLINE
| ID: mdl-34909706
ABSTRACT
Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, the composition of the cutaneous microbiome shifts as the disease progresses, although it is unclear whether this is a primary or secondary process. Trials with immunomodulatory therapy elucidate the role of specific immune pathways and cytokine signaling in disease mechanism, such as TNF-α, IL-1ß, IL-12, IL-17, IL-23, and complement. Future studies should continue examining the causes of and contributing factors to microbial changes and immune dysregulation in HS pathogenesis.
AMP, antimicrobial peptide; BD, ß-defensin; BMI, body mass index; DC, dendritic cell; DCD, dermcidin; GSC, γ-secretase complex; HS, hidradenitis suppurativa; HiSCR, hidradenitis suppurativa clinical response; IBD, inflammatory bowel disease; IHS4, International Hidradenitis Suppurativa Severity Score System; KC, keratinocyte; MMP, matrix metalloproteinase; NET, neutrophil extracellular traps; NMSC, nonmelanoma skin cancer; PG, pyoderma gangrenosum; RCT, randomized controlled trial; SAPHO, synovitis, acne, pustulosis, hyperostosis, and osteitis; TLR, toll-like receptor; Th, T helper type; iNOS, inducible nitric oxide synthase; pDC, plasmacytoid dendritic cell
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
JID Innov
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos