S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca<sup>2+</sup> signaling by Jurkat T cell receptors at the immune synapse.

Carreras-Sureda, Amado; Abrami, Laurence; Ji-Hee, Kim; Wang, Wen-An; Henry, Christopher; Frieden, Maud; Didier, Monica; van der Goot, F Gisou; Demaurex, Nicolas

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca²⁺ signaling by Jurkat T cell receptors at the immune synapse.

Carreras-Sureda, Amado; Abrami, Laurence; Ji-Hee, Kim; Wang, Wen-An; Henry, Christopher; Frieden, Maud; Didier, Monica; van der Goot, F Gisou; Demaurex, Nicolas.

Afiliación

Carreras-Sureda A; Department of Cell Physiology and Metabolism, Geneva, Switzerland.
Abrami L; Faculty of Life Sciences, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Ji-Hee K; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Wang WA; Department of Cell Physiology and Metabolism, Geneva, Switzerland.
Henry C; Department of Cell Physiology and Metabolism, Geneva, Switzerland.
Frieden M; Department of Cell Physiology and Metabolism, Geneva, Switzerland.
Didier M; Department of Cell Physiology and Metabolism, Geneva, Switzerland.
van der Goot FG; Faculty of Life Sciences, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Demaurex N; Department of Cell Physiology and Metabolism, Geneva, Switzerland.

Elife ; 102021 12 16.

Article en En | MEDLINE | ID: mdl-34913437

Asunto(s)

Aciltransferasas/genética; Calcio/metabolismo; Proteína ORAI1/genética; Receptores de Antígenos de Linfocitos T/metabolismo; Transducción de Señal; Acilación; Aciltransferasas/metabolismo; Células Presentadoras de Antígenos/metabolismo; Células HEK293; Humanos; Células Jurkat/metabolismo; Microdominios de Membrana/metabolismo; Proteína ORAI1/metabolismo; Azufre/metabolismo; Linfocitos T/metabolismo

Palabras clave

Jurkat; ORAI1; S-Acylation; T cell activation; immunology; inflammation; none

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aciltransferasas / Receptores de Antígenos de Linfocitos T / Transducción de Señal / Calcio / Proteína ORAI1 Límite: Humans Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Suiza

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