Citrobacter rodentium(ÏStx2dact), a murine infection model for enterohemorrhagic Escherichia coli.
Curr Opin Microbiol
; 65: 183-190, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34929548
ABSTRACT
The formation of attaching and effacing (A/E) lesions on intestinal epithelium, combined with Shiga toxin production, are hallmarks of enterohemorrhagic Escherichia coli (EHEC) infection that can lead to lethal hemolytic uremic syndrome. Although an animal infection model that fully recapitulates human disease remains elusive, mice orally infected with Citrobacter rodentium(ÏStx2dact), a natural murine pathogen lysogenized with an EHEC-derived Shiga toxin 2-producing bacteriophage, develop intestinal A/E lesions and toxin-dependent systemic disease. This model has facilitated investigation of how (A) phage gene expression and prophage induction contribute to disease and are potentially triggered by antibiotic treatment; (B) virulence gene expression is altered by microbiota and the colonic metabolomic milieu; and (C) innate immune signaling is affected by Stx. Thus, the model provides a unique tool for accessing diverse aspects of EHEC pathogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Bacteriófagos
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Infecciones por Escherichia coli
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Escherichia coli Enterohemorrágica
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Síndrome Hemolítico-Urémico
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Curr Opin Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2022
Tipo del documento:
Article