Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes.
Virology
; 566: 143-152, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34929590
ABSTRACT
Annual repeat influenza vaccination raises concerns about protective efficacy against mismatched viruses. We investigated the impact of heterologous prime-boost vaccination on inducing cross protection by designing recombinant influenza viruses with chimeric hemagglutinin (HA) carrying M2 extracellular domains (M2e-HA). Heterologous prime-boost vaccination of C57BL/6 mice with M2e-HA chimeric virus more effectively induced M2e and HA stalk specific IgG antibodies correlating with cross protection than homologous prime-boost vaccination. Induction of M2e and HA stalk specific IgG antibodies was compromised in 1-year old mice, indicating significant aging effects on priming subdominant M2e and HA stalk IgG antibody responses. This study demonstrates that a heterologous prime-boost strategy with recombinant influenza virus expressing extra M2e epitopes provides more effective cross protection than homologous vaccination.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_doencas_transmissiveis
/
2_enfermedades_transmissibles
Asunto principal:
Envejecimiento
/
Inmunoglobulina G
/
Vacunas contra la Influenza
/
Infecciones por Orthomyxoviridae
/
Glicoproteínas Hemaglutininas del Virus de la Influenza
/
Gripe Humana
/
Anticuerpos Antivirales
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Virology
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos