Mechanistic diversity in MHC class I antigen recognition.
Biochem J
; 478(24): 4187-4202, 2021 12 22.
Article
en En
| MEDLINE
| ID: mdl-34940832
ABSTRACT
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Receptores de Antígenos de Linfocitos T
/
Antígenos de Histocompatibilidad Clase I
/
Modelos Inmunológicos
/
Linfocitos T CD8-positivos
/
Antígenos
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem J
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido