Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA.

Zahn, Michael; König, Gerhard; Pham, Huy Viet Cuong; Seroka, Barbara; Lazny, Ryszard; Yang, Guangli; Ouerfelli, Ouathek; Lotowski, Zenon; Rohwerder, Thore

Zahn, Michael; König, Gerhard; Pham, Huy Viet Cuong; Seroka, Barbara; Lazny, Ryszard; Yang, Guangli; Ouerfelli, Ouathek; Lotowski, Zenon; Rohwerder, Thore.

Afiliación

Zahn M; Centre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom. Electronic address: michael.zahn@port.ac.uk.
König G; Centre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
Pham HVC; Department of Environmental Microbiology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
Seroka B; Faculty of Chemistry, University of Bialystok, Bialystok, Poland.
Lazny R; Faculty of Chemistry, University of Bialystok, Bialystok, Poland.
Yang G; Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.
Ouerfelli O; Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.
Lotowski Z; Faculty of Chemistry, University of Bialystok, Bialystok, Poland.
Rohwerder T; Department of Environmental Microbiology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany. Electronic address: thore.rohwerder@ufz.de.

J Biol Chem ; 298(1): 101522, 2022 01.

Article en En | MEDLINE | ID: mdl-34952003

Asunto(s)

Acilcoenzima A; Liasas; Acilcoenzima A/química; Acilcoenzima A/metabolismo; Carbono; Catálisis; Dominio Catalítico; Cristalografía por Rayos X; Humanos; Liasas/química; Liasas/metabolismo; Protones; Relación Estructura-Actividad; Especificidad por Sustrato

Palabras clave

2-hydroxyacyl-CoA synthase; Actinomycetospora; carbonyl compounds; formate assimilation; glycolyl-CoA; mono-carbon extension; oxalyl-CoA decarboxylase; x-ray diffraction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acilcoenzima A / Liasas Límite: Humans Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article

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