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Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.
Wu, Bing; Lyu, Yue Bin; Cao, Zhao Jin; Wei, Yuan; Shi, Wan Ying; Gao, Xiang; Zhou, Jin Hui; Kraus, Virginia Byers; Zhao, Feng; Chen, Xin; Lu, Feng; Zhang, Ming Yuan; Liu, Ying Chun; Tan, Qi Yue; Song, Shi Xun; Qu, Ying Li; Zheng, Xu Lin; Shen, Chong; Mao, Chen; Shi, Xiao Ming.
Afiliación
  • Wu B; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Lyu YB; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Cao ZJ; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Wei Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China;School of Public Health, Jilin University, Changchun 130012, Jilin, China.
  • Shi WY; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Gao X; Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, 19019, USA.
  • Zhou JH; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Kraus VB; Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
  • Zhao F; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Chen X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China;School of Public Health, Jilin University, Changchun 130012, Jilin, China.
  • Lu F; Beijing Municipal Health Commission Information Center, Beijing 100034, China.
  • Zhang MY; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China;School of Public Health, Jilin University, Changchun 130012, Jilin, China.
  • Liu YC; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Tan QY; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China;School of Public Health, Jilin University, Changchun 130012, Jilin, China.
  • Song SX; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Qu YL; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Zheng XL; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Shen C; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
  • Mao C; Division of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
  • Shi XM; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Biomed Environ Sci ; 34(11): 859-870, 2021 Nov 20.
Article en En | MEDLINE | ID: mdl-34955146
ABSTRACT

OBJECTIVE:

To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults.

METHODS:

Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment.

RESULTS:

The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio ( OR) for cognitive impairment in individuals with sarcopenia was 2.55 [95% confidence interval (95% CI) 1.86-3.50]. Compared with individuals in the first quartile (Q 1) of calf circumference, the adjusted ORs in the second, third, and fourth quartiles (Q 2, Q 3, and Q 4) were 0.75 (95% CI 0.58-0.96), 0.59 (95% CI 0.44-0.79), and 0.62 (95% CI 0.45-0.8), respectively. Compared with individuals in Q 1 of handgrip strength, the adjusted ORs for Q 2, Q 3, and Q 4 were 0.49 (95% CI 0.38-0.62), 0.31 (95% CI 0.23-0.41), and 0.30 (95% CI 0.21-0.44), respectively.

CONCLUSION:

Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fuerza de la Mano / Sarcopenia / Disfunción Cognitiva / Pierna Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fuerza de la Mano / Sarcopenia / Disfunción Cognitiva / Pierna Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2021 Tipo del documento: Article País de afiliación: China