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Relevant Characteristics Analysis Using Natural Language Processing and Machine Learning Based on Phenotypes and T-Cell Subsets in Systemic Lupus Erythematosus Patients With Anxiety.
Gu, Xi-Xi; Jin, Yi; Fu, Ting; Zhang, Xiao-Ming; Li, Teng; Yang, Ying; Li, Rong; Zhou, Wei; Guo, Jia-Xin; Zhao, Rui; Li, Jing-Jing; Dong, Chen; Gu, Zhi-Feng.
Afiliación
  • Gu XX; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
  • Jin Y; Joint Research Center, Affiliated Hospital of Nantong University, Nantong, China.
  • Fu T; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
  • Zhang XM; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
  • Li T; Joint Research Center, Affiliated Hospital of Nantong University, Nantong, China.
  • Yang Y; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
  • Li R; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
  • Zhou W; Joint Research Center, Affiliated Hospital of Nantong University, Nantong, China.
  • Guo JX; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
  • Zhao R; Joint Research Center, Affiliated Hospital of Nantong University, Nantong, China.
  • Li JJ; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
  • Dong C; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
  • Gu ZF; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Front Psychiatry ; 12: 793505, 2021.
Article en En | MEDLINE | ID: mdl-34955935
Anxiety is frequently observed in patients with systemic lupus erythematosus (SLE) and the immune system could act as a trigger for anxiety. To recognize abnormal T-cell and B-cell subsets for SLE patients with anxiety, in this study, patient disease phenotypes data from electronic lupus symptom records were extracted by using natural language processing. The Hospital Anxiety and Depression Scale (HADS) was used to distinguish patients, and 107 patients were selected to meet research requirements. Then, peripheral blood was collected from two patient groups for multicolor flow cytometry experiments. The characteristics of 75 T-cell and 15 B-cell subsets were investigated between SLE patients with- (n = 23) and without-anxiety (n = 84) groups by four machine learning methods. The findings showed 13 T-cell subsets were significantly different between the two groups. Furthermore, BMI, fatigue, depression, unstable emotions, CD27+CD28+ Th/Treg, CD27-CD28- Th/Treg, CD45RA-CD27- Th, and CD45RA+HLADR+ Th cells may be important characteristics between SLE patients with- and without-anxiety groups. The findings not only point out the difference of T-cell subsets in SLE patients with or without anxiety, but also imply that T cells might play the important role in patients with anxiety disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: China
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