L'intelligence artificielle pourrait-elle intervenir dans l'aide au diagnostic des cancers du sein ? ­ L'exemple de HER2: Could artificial intelligence play a role in breast cancer diagnosis? ­ The example of HER2.

ABSTRACT

HER2 is an important prognostic and predictive biomarker in breast cancer. Its detection makes it possible to define which patients will benefit from a targeted treatment. While assessment of HER2 status by immunohistochemistry in positive vs negative categories is well implemented and reproducible, the introduction of a new "HER2-low" category could raise some concerns about its scoring and reproducibility. We herein described the current HER2 testing methods and the application of innovative machine learning techniques to improve these determinations, as well as the main challenges and opportunities related to the implementation of digital pathology in the up-and-coming AI era.