Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms.
Drug Deliv Transl Res
; 12(8): 1843-1858, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-34988827
ABSTRACT
In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery systems. This review focuses on spray congealing and mechanochemical activation, two technologies endorsing different principles of green chemistry, and at the same time, addressing some of the challenges related to the transformation of poorly water-soluble drugs in highly bioavailable solid dosage forms. We therefore present an overview of the basic principles, equipment, and application of these particle-engineering technologies, with specific attention to case studies carried out by the groups working in Italian Universities.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tecnología Farmacéutica
/
Sistemas de Liberación de Medicamentos
Idioma:
En
Revista:
Drug Deliv Transl Res
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia