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Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction.
Spasov, A A; Kucheryavenko, A F; Khaliullin, F A; Gurova, N A; Sirotenko, V S; Samorodov, A V; Gaidukova, K A; Pavlov, V N.
Afiliación
  • Spasov AA; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Kucheryavenko AF; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Khaliullin FA; Department of Pharmaceutical Chemistry with Courses of Analytical and Toxicological Chemistry, Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, the Republic of Bashkortostan, Russia.
  • Gurova NA; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Sirotenko VS; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. sirotenko.viktor@yandex.ru.
  • Samorodov AV; Department of Pharmaceutical Chemistry with Courses of Analytical and Toxicological Chemistry, Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, the Republic of Bashkortostan, Russia.
  • Gaidukova KA; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Pavlov VN; Department of Pharmaceutical Chemistry with Courses of Analytical and Toxicological Chemistry, Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, the Republic of Bashkortostan, Russia.
Bull Exp Biol Med ; 172(3): 314-317, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35001313
ABSTRACT
We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, Angipur administered intravenously was 1.2 times less effective, in terms of ED50, than the well-known inhibitor of GPIIb/IIIa platelet receptors tirofiban. However, under conditions of non-coronary myocardial infarction, Angipur significantly prolonged the time of thrombus formation and exhibited 1.4-fold higher activity than the reference drug tirofiban.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Infarto del Miocardio Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Infarto del Miocardio Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia