Comparing the Efficacy of Intravitreal Dexamethasone and Time-displaced Fluocinolone Acetonide on Central Retinal Thickness in Patients with Uveitis.
Ocul Immunol Inflamm
; 31(1): 168-174, 2023 Jan.
Article
en En
| MEDLINE
| ID: mdl-35081001
ABSTRACT
BACKGROUND:
To compare the efficacy of intravitreally administered dexamethasone (Dex) and subsequent time-displaced fluocinolone acetonide (FA) on central subfield thickness (CST) in eyes with noninfectious uveitis.METHODS:
Retrospective analysis of twenty-three eyes (18 patients) subsequently receiving intravitreal Dex and FA implants. The main outcome measures were CST, best-corrected visual acuity (BCVA), intraocular pressure (IOP), and status of inflammation.RESULTS:
CST (Dex p < .0001; FA p = .0008) and BCVA (Dex p = .0009; FA p = .0005) improved significantly with both implants. Significantly better effects were noted with Dex for absolute and relative CST reduction (p = .0089 and p = .0051, respectively). Final BCVA did not differ between groups (p = .1893). Dex significantly increased IOP, whereas FA did not. One eye was actively inflamed after Dex and FA injection at follow-up (inflamed eyes before injection [Dex 2; FA 6]).CONCLUSION:
Both implants significantly reduced CST and induced a significant gain in visual acuity. Dex might be more effective in reducing CST.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Uveítis
/
Fluocinolona Acetonida
Límite:
Humans
Idioma:
En
Revista:
Ocul Immunol Inflamm
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
OFTALMOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania