Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment.
Nanotechnology
; 33(20)2022 Feb 21.
Article
en En
| MEDLINE
| ID: mdl-35100566
ABSTRACT
Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel and MHT, separately or combined. The time evolution of the tumor volume is successfully modeled using the logistic mathematical model. The combined therapy comprising NcSel and MHT is able to hinder primary tumor growth and a case of complete tumor remission is recorded. Moreover, no metastasis was diagnosed and the adverse effects are negligible. NcSel plus MHT may represent an effective and safe alternative to cancer control in aged patients. Future clinical trials are encouraged.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Compuestos de Selenio
/
Nanocápsulas
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Nanopartículas de Magnetita
/
Hipertermia Inducida
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Nanotechnology
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil