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The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
Abdelnabi, Rana; Foo, Caroline S; Jochmans, Dirk; Vangeel, Laura; De Jonghe, Steven; Augustijns, Patrick; Mols, Raf; Weynand, Birgit; Wattanakul, Thanaporn; Hoglund, Richard M; Tarning, Joel; Mowbray, Charles E; Sjö, Peter; Escudié, Fanny; Scandale, Ivan; Chatelain, Eric; Neyts, Johan.
Afiliación
  • Abdelnabi R; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000, Leuven, Belgium.
  • Foo CS; Global Virus Network, GVN, Baltimore, MD, USA.
  • Jochmans D; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000, Leuven, Belgium.
  • Vangeel L; Global Virus Network, GVN, Baltimore, MD, USA.
  • De Jonghe S; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000, Leuven, Belgium.
  • Augustijns P; Global Virus Network, GVN, Baltimore, MD, USA.
  • Mols R; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000, Leuven, Belgium.
  • Weynand B; Global Virus Network, GVN, Baltimore, MD, USA.
  • Wattanakul T; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000, Leuven, Belgium.
  • Hoglund RM; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery & Disposition, Box 921, 3000, Leuven, Belgium.
  • Tarning J; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery & Disposition, Box 921, 3000, Leuven, Belgium.
  • Mowbray CE; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.
  • Sjö P; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Escudié F; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Scandale I; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Chatelain E; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Neyts J; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Nat Commun ; 13(1): 719, 2022 02 15.
Article en En | MEDLINE | ID: mdl-35169114
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 4_TD Problema de salud: 1_doencas_nao_transmissiveis / 1_doencas_transmissiveis / 4_pneumonia Asunto principal: Prolina / Modelos Animales de Enfermedad / Inhibidores de Proteasa Viral / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 / Lactamas / Leucina / Nitrilos Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 4_TD Problema de salud: 1_doencas_nao_transmissiveis / 1_doencas_transmissiveis / 4_pneumonia Asunto principal: Prolina / Modelos Animales de Enfermedad / Inhibidores de Proteasa Viral / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 / Lactamas / Leucina / Nitrilos Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Bélgica