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The Role of Zinc in Bone Mesenchymal Stem Cell Differentiation.
Li, Huiyun; Li, Muzhe; Ran, Xun; Cui, Juncheng; Wei, Fu; Yi, Guoliang; Chen, Wei; Luo, Xuling; Chen, Zhiwei.
Afiliación
  • Li H; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Li M; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Ran X; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Cui J; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Wei F; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Yi G; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Chen W; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Luo X; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
  • Chen Z; Department of Orthopedic Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.
Cell Reprogram ; 24(2): 80-94, 2022 04.
Article en En | MEDLINE | ID: mdl-35172118
ABSTRACT
Zinc is an essential trace element for bone growth and bone homeostasis in the human body. Bone mesenchymal stem cells (BMSCs) are multipotent progenitors existing in the bone marrow stroma with the capability of differentiating along multiple lineage pathways. Zinc plays a paramount role in BMSCs, which can be spurred differentiating into osteoblasts, chondrocytes, or adipocytes, and modulates the formation and activity of osteoclasts. The expression of related genes also changed during the differentiation of various cell phenotypes. Based on the important role of zinc in BMSC differentiation, using zinc as a therapeutic approach for bone remodeling will be a promising method. This review explores the role of zinc ion in the differentiation of BMSCs into various cell phenotypes and outlines the existing research on their molecular mechanism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Células Madre Mesenquimatosas Idioma: En Revista: Cell Reprogram Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Células Madre Mesenquimatosas Idioma: En Revista: Cell Reprogram Año: 2022 Tipo del documento: Article País de afiliación: China