STATE OF MICROCIRCULATION AND FREE-RADICAL PROCESSES OF PERIODONTAL TISSUES IN SMOKING DEPENDENT PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CHRONIC HYPERACID GASTRITIS.

ABSTRACT

OBJECTIVE: The aim: The aim of the work was to determine the state of microcirculation and free radical processes of periodontal tissues in smoking dependent patients with chronic generalized periodontitis associated with chronic hyperacid gastritis. PATIENTS AND METHODS: Materials and methods: We examined 90 patients (men and women) aged 25 to 44 years, who were divided into 3 groups the first group - 48 smoking patients with chronic generalized periodontitis and chronic hyperacid gastritis associated with Helicobacter pylori; the second group - 22 patients with chronic generalized periodontitis and chronic hyperacid gastritis associated with Helicobacter pylori, without the bad habit; the third group - control, consisted of 20 healthy individuals. The smoking patients were randomly divided into two subgroups patients of the first subgroup (G1.1) received the basic therapy of chronic generalized periodontitis and the proposed treatment and prevention complex; the patients in the second subgroup (G1.2) received basic therapy for chronic generalized periodontitis and ultraphonophoresis with placebo. RESULTS: Results: The use of treatment and prevention complex in smoking dependent patients and patients without the bad habit with chronic generalized periodontitis and chronic hyperacid gastritis associated with Helicobacter pylori demonstrated a positive dynamics of the functional characteristics of microcirculation and the balance in the lipid peroxidation - antioxidant system. CONCLUSION: Conclusions: So, the use of the proposed treatment and prevention complex had a positive effect on the state of microcirculation and free radical processes of periodontal tissues both at the near and long-term follow up, even under conditions of chronic hyperacid gastritis and the risk factor - smoking.