Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women.
J Hum Reprod Sci
; 14(4): 372-379, 2021.
Article
en En
| MEDLINE
| ID: mdl-35197682
ABSTRACT
BACKGROUND:
Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals.AIM:
This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile women and to find the proportion of young women with low ovarian reserve. SETTING ANDDESIGN:
This was a retrospective data analysis of AMH and AFC of 5525 infertile women from August 2015 to December 2018. MATERIALS ANDMETHODS:
Infertile women aged 20- 44 years, with body mass index 18-32 kg/m2 and having both ovaries were included in the study. Women with pituitary/adrenal disorders, malignancy, total AFC >40, tuberculosis, endometriosis, autoimmune disorders, smoking, chemotherapy, radiotherapy and recent ovarian surgery were excluded from the study. STATISTICALANALYSIS:
Comparison between groups was done by Chi-square test.RESULTS:
About 14.5% of women <35 years and 50.5% of women >35 years had low AMH values (<1.1 ng/ml). In addition, 5.6% of women <35 years and 23.6% of women >35 years had a low AFC of ≤5. In this study, 55.7% of women who had low AMH and 50.7% who had low AFC were <35 years of age. The median AMH values were 4.23 ng/mL in 20-25 years' age group, 3.48 ng/mL in women aged 26-30 years, 2.43 ng/mL in women aged 31-35 years, 1.28 ng/mL in women aged 36-40 years and0.52 ng/mL in 40-44 years' age group. The median AFCs were 20, 18, 14, 10 and 6 for each of the age groups, respectively.CONCLUSION:
This study suggests that approximately more than half of the infertile women who were tested to have low ovarian reserve were <35 years of age.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_tuberculosis
Idioma:
En
Revista:
J Hum Reprod Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
India