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Organoid Studies in COVID-19 Research.
Kim, Jihoon; Koo, Bon-Kyoung; Clevers, Hans.
Afiliación
  • Kim J; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Korea.
  • Koo BK; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, Austria.
  • Clevers H; Center for Genome Engineering, Institute for Basic Science, Daejeon, Korea.
Int J Stem Cells ; 15(1): 3-13, 2022 Feb 28.
Article en En | MEDLINE | ID: mdl-35220288
ABSTRACT
The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has completely changed human life for more than two years. Upon the emergence of this new lethal virus, multiple approaches were utilized to gain basic knowledge about its biology. Moreover, modern technologies, such as the organoid model system and next-generation sequencing, enabled us to rapidly establish strategies to tackle the disease, including vaccines and therapeutics. The recently developed organoid technology reflects human physiology more closely than other model systems. Coupled with its rapidness, high efficiency, and outstanding reliability, it has provided an opportunity to develop new drugs and understand the impact of the viral pathogen on the host. Recent findings using organoids have successfully revealed the cellular tropism of the virus in different organs and identified potential drug candidates that impact the disease. This review will summarize current achievements made with organoids in the fight against COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Stem Cells Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Stem Cells Año: 2022 Tipo del documento: Article
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