The Pandemic Response BoxâAccelerating Drug Discovery Efforts after Disease Outbreaks.
ACS Infect Dis
; 8(4): 713-720, 2022 04 08.
Article
en En
| MEDLINE
| ID: mdl-35286809
ABSTRACT
The current Covid-19 pandemic has underlined the need for a more coordinated and forward-looking investment in the search for new medicines targeting emerging health care threats. Repositioning currently approved drugs is a popular approach to any new emerging disease, but it represents a first wave of response. Behind this would be a second wave of more specifically designed therapies based on activities against specific molecular targets or in phenotypic assays. Following the successful deployment and uptake of previous open access compound collections, we assembled the Pandemic Response Box, a collection of 400 compounds to facilitate drug discovery in emerging infectious disease. These are based on public domain information on chemotypes currently in discovery and early development which have been shown to have useful activities and were prioritized by medicinal chemistry experts. They are freely available to the community as a pharmacological test set with the understanding that data will be shared rapidly in the public domain.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_medicamentos_vacinas_tecnologias
Asunto principal:
Pandemias
/
Tratamiento Farmacológico de COVID-19
Límite:
Humans
Idioma:
En
Revista:
ACS Infect Dis
Año:
2022
Tipo del documento:
Article
País de afiliación:
Suiza