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Changes in miR-124-1, miR-212, miR-132, miR-134, and miR-155 Expression Patterns after 7,12-Dimethylbenz(a)anthracene Treatment in CBA/Ca Mice.
Tomesz, Andras; Szabo, Laszlo; Molnar, Richard; Deutsch, Arpad; Darago, Richard; Raposa, Bence L; Ghodratollah, Nowrasteh; Varjas, Timea; Nemeth, Balazs; Orsos, Zsuzsanna; Pozsgai, Eva; Szentpeteri, Jozsef L; Budan, Ferenc; Kiss, Istvan.
Afiliación
  • Tomesz A; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
  • Szabo L; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Molnar R; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
  • Deutsch A; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Darago R; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
  • Raposa BL; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Ghodratollah N; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
  • Varjas T; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
  • Nemeth B; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
  • Orsos Z; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Pozsgai E; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Szentpeteri JL; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Budan F; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
  • Kiss I; Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Cells ; 11(6)2022 03 17.
Article en En | MEDLINE | ID: mdl-35326471
ABSTRACT
Specific gene and miRNA expression patterns are potential early biomarkers of harmful environmental carcinogen exposures. The aim of our research was to develop an assay panel by using several miRNAs for the rapid screening of potential carcinogens. The expression changes of miR-124-1, miR-212, miR-132, miR-134, and miR-155 were examined in the spleen, liver, and kidneys of CBA/Ca mice, following the 20 mg/bwkg intraperitoneal 7,12-dimethylbenz(a)anthracene (DMBA) treatment. After 24 h RNA was isolated, the miRNA expressions were analyzed by a real-time polymerase chain reaction and compared to a non-treated control. DMBA induced significant changes in the expression of miR-134, miR-132, and miR-124-1 in all examined organs in female mice. Thus, miR-134, miR-132, and miR-124-1 were found to be suitable biomarkers for the rapid screening of potential chemical carcinogens and presumably to monitor the protective effects of chemopreventive agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / 9,10-Dimetil-1,2-benzantraceno Límite: Animals Idioma: En Revista: Cells Año: 2022 Tipo del documento: Article País de afiliación: Hungria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / 9,10-Dimetil-1,2-benzantraceno Límite: Animals Idioma: En Revista: Cells Año: 2022 Tipo del documento: Article País de afiliación: Hungria