Your browser doesn't support javascript.
loading
Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.
Park, Bo-Yong; Larivière, Sara; Rodríguez-Cruces, Raul; Royer, Jessica; Tavakol, Shahin; Wang, Yezhou; Caciagli, Lorenzo; Caligiuri, Maria Eugenia; Gambardella, Antonio; Concha, Luis; Keller, Simon S; Cendes, Fernando; Alvim, Marina K M; Yasuda, Clarissa; Bonilha, Leonardo; Gleichgerrcht, Ezequiel; Focke, Niels K; Kreilkamp, Barbara A K; Domin, Martin; von Podewils, Felix; Langner, Soenke; Rummel, Christian; Rebsamen, Michael; Wiest, Roland; Martin, Pascal; Kotikalapudi, Raviteja; Bender, Benjamin; O'Brien, Terence J; Law, Meng; Sinclair, Benjamin; Vivash, Lucy; Kwan, Patrick; Desmond, Patricia M; Malpas, Charles B; Lui, Elaine; Alhusaini, Saud; Doherty, Colin P; Cavalleri, Gianpiero L; Delanty, Norman; Kälviäinen, Reetta; Jackson, Graeme D; Kowalczyk, Magdalena; Mascalchi, Mario; Semmelroch, Mira; Thomas, Rhys H; Soltanian-Zadeh, Hamid; Davoodi-Bojd, Esmaeil; Zhang, Junsong; Lenge, Matteo; Guerrini, Renzo.
Afiliación
  • Park BY; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Larivière S; Department of Data Science, Inha University, Incheon, Republic of Korea.
  • Rodríguez-Cruces R; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
  • Royer J; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Tavakol S; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Wang Y; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Caciagli L; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Caligiuri ME; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Gambardella A; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
  • Concha L; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK.
  • Keller SS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Cendes F; Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
  • Alvim MKM; Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
  • Yasuda C; Institute of Neurology, University Magna Græcia, Catanzaro, CZ, Italy.
  • Bonilha L; Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.
  • Gleichgerrcht E; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Focke NK; Walton Centre NHS Foundation Trust, Liverpool, UK.
  • Kreilkamp BAK; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
  • Domin M; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
  • von Podewils F; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
  • Langner S; Department of Neurology, Emory University, Atlanta, GA, USA.
  • Rummel C; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
  • Rebsamen M; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
  • Wiest R; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
  • Martin P; Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.
  • Kotikalapudi R; Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
  • Bender B; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
  • O'Brien TJ; Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
  • Law M; Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
  • Sinclair B; Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
  • Vivash L; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  • Kwan P; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  • Desmond PM; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
  • Malpas CB; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
  • Lui E; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
  • Alhusaini S; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Doherty CP; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
  • Cavalleri GL; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
  • Delanty N; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Kälviäinen R; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
  • Jackson GD; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Kowalczyk M; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
  • Mascalchi M; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Semmelroch M; Department of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Thomas RH; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Soltanian-Zadeh H; Department of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
  • Davoodi-Bojd E; Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Zhang J; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
  • Lenge M; Department of Neurology, St James' Hospital, Dublin, Ireland.
  • Guerrini R; FutureNeuro SFI Research Centre, Dublin, Ireland.
Brain ; 145(4): 1285-1298, 2022 05 24.
Article en En | MEDLINE | ID: mdl-35333312
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsia del Lóbulo Temporal / Conectoma Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Brain Año: 2022 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsia del Lóbulo Temporal / Conectoma Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Brain Año: 2022 Tipo del documento: Article País de afiliación: Canadá